Little did they know, it was game over. Binding of Isaac Four Souls is one of my favourite games and started my board game collection. Can't wait for the expansion to arrive Number Two The Binding of Isaac: Four Souls: A complete reference for The Binding of Isaac: Four Souls card game. Four Souls Subreddit Now that the new cards have been revealed, lets recap the Edmund Booster Pack for Four Souls! This pack adds 15 thrilling new cards inspired by the legendary game Binding Of Isaac, Edmund McMillen, The Binding of Isaac: Four Souls and its Requiem expansion will take you to dark places! Big Boss Battle (B3) The Binding of Isaac Card Game: Mystery, Strategy, and Excitement!